Neuromuscular Alterations Associated with COVID-19. A Scientific Literature Review

Alteraciones neuromusculares asociadas a la COVID-19. Revisión de la literatura científica


Introduction. The COVID-19 pandemic has brought short, medium, and long-term consequences on the quality of life of those affected. Among the complications are those related to the involvement of the nervous system and the structures involved in body movement, with sequelae that may be transitory and/or definitive, and require rehabilitation.

Objective. Identify the neuromuscular alterations that affect body movement, associated with COVID-19.

Material and methods. A search was made for observational works published in the SCOPUS, PubMed, EBSCO, and Nature databases between January 2020 and June 2022 under the PRISMA methodology, to answer the PICO question: what are the neuromuscular alterations that can potentially affect movement, associated with COVID-19? The established filters were type of study, language, age, availability, publication dates. The MeSH terms were SARS-Cov-2, COVID-19, Long Covid, Motor Activity Neuromuscular Diseases, Neurological Disorders, Guillain-Barré Syndrome, Myelitis Transverse, Stroke, Patient, Peripheral Nervous System Diseases. The methodological quality was evaluated according to STROBE and the level of evidence was established according to CEBM.

Results. In the first search, 645 articles were identified. 637 were discarded by filters, titles, duplicate abstracts, methodological quality, and level of evidence. There were 8 articles selected for the present review, in which neuromuscular alterations of central and peripheral origin were identified, such as myalgias, fatigue, polyneuroradiculopathies, CNS inflammation, among others, with clinical manifestations that affect movement.

Conclusion. COVID-19 is a multisystemic disease that can affect the nervous system with symptoms of neuromuscular alterations that compromise body movement.


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Citado por


Eulalia Maria Amador-Rodero
Priscila Mishelle Bartolo Gómez
Fátima del Carmen Carrasco Ferrer
Nancy Paola Ochoa Castillo
Leslie Piedad Montealegre Esmeral
Roberto Carlos Rebolledo Cobos


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